What happens inside a tennis player’s brain as they try to return a 148mph serve?


Michelle Spear, University of Bristol

The fastest serve so far at this year’s Wimbledon tennis championships was struck by the Argentinian Thiago Agustín Tirante on the opening day.

His serve of almost 148mph (238km/h) was still some way under the Wimbledon record of 153mph, set by Frenchman Giovanni Mpetshi Perricard in 2025. And despite Tirante giving his opponent less than a fifth of a second to play each serve, he lost the match in straight sets.

Which means his rocket serves were successfully returned on lots of points. Our emerging understanding of how the human brain works can help explain how this feat is achieved.

Whether you’re a player or a spectator, the ability to see a tennis ball travelling that quickly across the court is a marvel of human physiology. At nearly 150mph, the ball is travelling faster than anyone can watch it move.

By the time your brain has processed the sight of the ball leaving the racket, it is already well on its way to the other end of the court. Yet professional tennis players return these high-powered serves with astonishing accuracy.

The reason is that they do not rely on reaction alone. Returning a tennis serve depends on one of the brain’s most remarkable abilities: predicting the future.

Predicting the future

Tennis players – and spectators – face the same basic problem: the visual information arrives in their brain slightly late.

Before a player becomes aware of a tennis ball hurtling across the court, light reflected from its surface has to be detected by their eyes’ retinas, converted into electrical signals, then transmitted along the optic nerves to the brain. There, the visual cortex begins analysing its colour, shape, speed and direction.

Even under ideal conditions, this takes around a tenth of a second. During that time, a ball travelling at nearly 148mph will have covered several metres.

For a spectator, this delay is rarely noticeable. The brain’s predictions are so accurate that the ball appears to move smoothly across the court, despite what you are seeing being a fraction of a second out of date.

But the player standing at the other end of the court needs to do a lot more than just watch the ball. They must move their body to that specific point on the court, position their racket and time their swing with great precision if they want to be in with a chance of winning the point.

In fact, much of this process begins before the ball has even left the opponent’s racket. It is an extraordinarily complex system.

How the brain works it all out

As the server prepares to strike the tennis ball, the receiver is already gathering information. The height and position of the ball toss, the rotation of the server’s trunk, the movement of their shoulder and forearm, the angle of the racket face and the speed of the swing all provide clues about what is about to happen.

Elite players have, of course, spent many thousands of hours learning to recognise these subtle biomechanical cues. Their brains combine the latest cues with all that previous experience to estimate the likely speed, direction and spin of the serve – before the ball has even crossed the net.

Central to this is the cerebellum, a densely folded structure tucked beneath the back of the brain. Although best known for coordinating movement and balance, advances in brain imaging and computational neuroscience have revealed it is also one of the brain’s great prediction engines.

Rather than simply responding to sensory information as it arrives, the cerebellum continuously generates internal models of how the body and external world behave. As fresh visual information reaches the brain, these models are updated almost instantaneously, allowing movements to be adjusted before conscious awareness has caught up.

But the cerebellum does not work alone. A specialised region of the visual cortex, known as area MT or V5, is exquisitely sensitive to movement, and calculates the speed and direction of the ball as it crosses the player’s visual field.

This information travels along the dorsal visual stream – often called the brain’s “where pathway” – to the posterior parietal cortex, where the ball’s position is integrated with information about the player’s own body.

The brain’s two visual streams

From there, premotor regions begin preparing possible movements. The supplementary motor area helps organise their sequence, and the primary motor cortex sends commands to the muscles of the trunk, shoulder, arm and wrist.

At the same time, the frontal eye fields and the superior colliculus (a small structure in the midbrain that rapidly redirects the eyes towards objects of interest) generate rapid eye movements towards where the ball is expected to be next – rather than where it was a fraction of a second ago.

This is why the fastest returns in tennis are not simply feats of lightning-fast reflexes. They are the product of a brain that is constantly making, testing and refining predictions. The players who appear to have more time have become exceptionally good at anticipating what will happen next.

Tennis and beyond

Neuroscientists are still trying to understand why some tennis players acquire these remarkable predictive skills faster than others. Is it simply a matter of hours spent on court, or are some brains naturally better equipped to build the internal models that underpin elite performance?

For now, the answer appears to be a combination of both.

Understanding how the brain predicts movement has implications far beyond tennis. Similar neural mechanisms help us catch a falling glass before it hits the floor, judge when it is safe to cross a busy road, or drive through traffic.

These predictive systems are becoming an important focus of neuroscience research. Insights into how the cerebellum and wider motor networks anticipate movement are helping researchers improve rehabilitation after neurological injury, understand disorders of movement and coordination, and design robots capable of interacting more naturally with an unpredictable world.

Meanwhile, insights from neuroscience might also help hone a future Wimbledon tennis champion.The Conversation

Michelle Spear, Professor of Anatomy, University of Bristol

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Drones are Saving Hundreds of Fawns From Mower Deaths in Germany (WATCH)

Credit: Erika Fletcher

A Bavarian wildlife rescue organization is using thermal imaging drones to locate and rescue vulnerable fawns hidden in tall meadow grass ahead of the annual mowing season.

Every spring, thousands of fawns are killed by mowing machinery across Germany. Baby deer instinctively freeze when threatened, a natural defense mechanism that protects them from predators but leaves them vulnerable to farm equipment.

Traditionally, this work was done on foot—with volunteers walking through the meadows in lines—an extremely labor-intensive task for this volunteer rescue group founded in 2020.

Now, with the thermal imaging of DJI drones, the rescue group, Rehkitz-Rettung Mangfalltal, can locate these hidden animals more quickly and efficiently before mowing begins, especially with the drone’s AI technology features that help pilots reliably spot fawns, baby hares, and ground-nesting birds.

Since integrating drone technology into their workflow, the group’s annual count of rescued fawns has ballooned from 10-15 in previous years to between 300 and 350 fawns today.

In a case study, operators used the Matrice 4 Series’ precision positioning controls to spot heat signatures in vegetation, verify them visually, and direct ground teams to the exact location. (See the video below…)

Whenever the thermal camera detects a heat source, its location is pinned with centimeter-level accuracy using the drone’s GPS and shared instantly with the ground team.

The German case study also provides a video step-by-step guide on the rescue process, including drone operations from an altitude of 80–100 meters and how to handle fawns once they are found.Thanks to the Rehkitz-Rettung Mangfalltal volunteers and drone pilots, farmers are able to happily proceed with mowing—confident that fields have been safely cleared of hidden animals. WATCH the Reuters news video below… Drones are Saving Hundreds of Fawns From Mower Deaths in Germany (WATCH)
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EV Charging Answer: Quantum Technology Will Cut Time it Takes to Charge Electric Cars to Just 9 Seconds

Institute for Basic Science

Scientists in South Korea have proven that a new technology will cut the time it takes to charge electric cars to just nine seconds, allowing EV owners to ‘fill up’ faster than their gasoline counterparts.

And even those plugging-in at home will have the time slashed from 10 hours to three minutes.

The new device uses the laws of quantum physics to power all of a battery’s cells at once—instead of one at a time—so recharging takes no longer than filling up at the pump.

Electric cars were rarely seen on the roads 10 years ago, but millions are now being sold every year and it has become one of the fastest growing industries, but even the fastest superchargers need around 20 to 40 minutes to power their car.

Scientists at the Institute for Basic Science (IBS) in South Korea have come up with a solution. Co-author Dr. Dario Rosa said the consequences could be far-reaching.

“Quantum charging could go well beyond electric cars and consumer electronics. For example, it may find key uses in future fusion power plants, which require large amounts of energy to be charged and discharged in an instant.”

The concept of a “quantum battery” was first proposed in a seminal paper published by Alicki and Fannes in 2012. It was theorized that quantum resources, such as entanglement, can be used to vastly speed up battery charging.

The researchers used quantum mechanics to model their super fast charging station with calculations of the charging speed showing that a typical electric vehicle with a battery containing around 200 cells would recharge 200 times faster.

Current collective charging is not possible in classical batteries, where the cells are charged in parallel, independently of one another.

“This is particularly exciting as modern large-capacity batteries can contain numerous cells.”

The group went further to provide an explicit way of designing such batteries.

This means charging times could be cut from 10 hours to three minutes at home and from around 30 minutes to just a few seconds at stations.

Co-author Dr Dominik Å afránek said, “Of course, quantum technologies are still in their infancy and there is a long way to go before these methods can be implemented in practice.”

“Research findings such as these, however, create a promising direction and can incentivize the funding agencies and businesses to further invest in these technologies.

“If employed, it is believed that quantum batteries would completely revolutionize the way we use energy and take us a step closer to our sustainable future.”

The findings were published in the February 8 edition of the journal Physical Review Letters. [GNN updated the earlier broken link.] EV Charging Answer: Quantum Technology Will Cut Time it Takes to Charge Electric Cars to Just 9 Seconds
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Application lodged to build microreactor at US university

A rendering of the KRONOS plant at the University of Illinois Urbana-Champaign (Image: NANO Nuclear)

The US Nuclear Regulatory Commission announced it has received an application from the University of Illinois to construct the first research KRONOS micro modular reactor on the university's campus.

The Construction Permit Application (CPA) was submitted on 31 March by The Grainger College of Engineering at the University of Illinois Urbana-Champaign, NANO Nuclear Energy Inc's partner for the KRONOS MMR deployment at the University of Illinois (U of I).

"With this submission, NANO Nuclear becomes the first commercially-ready microreactor developer and the third commercially-ready Generation IV advanced reactor developer to submit a CPA, placing NANO Nuclear among a small group of advanced nuclear companies progressing toward commercial deployment," the company said.

It added: "The preparation of a CPA represents the culmination of years of engineering development, thousands of pages of technical documentation, coordinated input across reactor design, safety analysis, environmental review, and regulatory compliance disciplines, and establishment of a viable supply chain. In NANO Nuclear's partnership with the U of I, the CPA submission builds on an extensive body of work developed through continuous engagement with the NRC, including completion of the readiness assessment, a voluntary but highly rigorous process aimed at ensuring a complete and high-quality application. Importantly, this iterative process reflects a high level of alignment with regulatory expectations and provides strong confidence in the application's readiness for acceptance for docketing and formal NRC review."

"The NRC is reviewing the application to determine whether it is complete," the regulator said. "If accepted, the agency will begin a detailed technical evaluation of the reactor's safety and security and publish a notice of opportunity to request an adjudicatory hearing on the application before the NRC's Atomic Safety and Licensing Board."

It noted that if the construction permit is granted, the university would need to submit a separate operating licence application and receive NRC approval before the reactor could begin operation.

NANO Nuclear acquired the Micro Modular Reactor Energy System technology through its USD85 million acquisition of Ultra Safe Nuclear Corporation's nuclear technology, which was completed in January last year. At that time, NANO Nuclear renamed the technology as the KRONOS MMR. The MMR is a 45 MW thermal, 15 MW electrical high-temperature gas-cooled reactor, using TRISO fuel in prismatic graphite blocks and has a sealed transportable core.

NANO Nuclear signed a strategic collaboration agreement with the University of Illinois Urbana-Champaign in April 2025 to construct the first research KRONOS micro modular reactor on the university's campus. The agreement formally established the University of Illinois Urbana-Champaign as a partner in the licensing, siting, public engagement, and research operation of the KRONOS MMR, while also identifying the university campus as the permanent site for the reactor as a research and demonstration installation.

The university plans to re-power partially its coal-fired Abbott power station with the KRONOS MMR, providing a zero-carbon demonstration of district heat and power to campus buildings as part of its green campus initiative. The project team aims to demonstrate how microreactor systems integrate with existing fossil fuel infrastructure to accelerate the decarbonisation of existing power-generation facilities."Through every step of the process thus far, we at The Grainger College of Engineering have worked diligently alongside our partners at NANO Nuclear Energy to ensure our goals in constructing the first KRONOS MMR on the university's campus can become a reality," said Caleb Brooks, Professor and Donald Biggar Willett Faculty Scholar of Nuclear, Plasma and Radiological Engineering at The Grainger College of Engineering. "By submitting the Construction Permit Application to the NRC, we are taking the next step in signifying that the work will be done correctly and precisely. And we continue to look forward to the possibilities of what can become the most advanced nuclear research platform on any US campus." Application lodged to build microreactor at US university
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Scientists Have Found Climate-Resistant Coral Reefs Around the World Totaling the Size of Wisconsin



A sophisticated AI-powered examination of coral reef resistance extrapolated into the future found that there’re about 64,000 square miles of coral reefs on Earth that could still be resisting climate change by 2050.

The common theory states that CO2 emissions create a greenhouse effect which warms the seas which causes coral reefs to bleach or even die, yet there are environments—as GNN has frequently reported—where corals seem to be more resilient.


The authors of this new study found that when they used 45,000 observations of coral reefs going back as far as 1960 as the data set for an AI model to examine, it predicted according to 46 different criteria that 25 years from now there’d still be swaths of coal reefs totaling the size of Wisconsin located primarily in 8 countries, and that these would be capable of surviving and thriving in the warming seas.

The findings were presented at Our Ocean Conference in Mombasa, Kenya, and are available on the preprint server EcoEvoRxiv.

Most of the coral distribution was plotted out in the Philippines, Indonesia, Cuba, the Bahamas, and Australia. Belize, Nicaragua, and the Turks and Caicos Islands also showed coral resilience in 2050 according to the estimates.

The criteria for where in the world the AI would map as good coral habitat comes from a concept of ‘coral refuges’ which are observations that coral species can either endure warming seas, recover from damage faster, or avoid damage altogether in certain places.

Where these are in the world comes from the 45,000 observations mentioned earlier.

Why coral seem to enjoy these conditions in these particular places isn’t exactly clear—particularly as regards Nicaragua’s neighbor Honduras, where the country’s largest coral reef is also the victim of substantial ecosystem disturbance by human activity, yet seems to be flourish year round.

Sara Hashemi, a daily correspondent at Smithsonian Magazine, wrote that the authors of the new study want their work “to offer a road map for where countries should invest conservation funding, especially for small nations with limited resources.”

Hashemi started her report by noting that “it’s hard to feel optimistic for coral reefs” these days. It’s hard—if one doesn’t read GNN.

There’s great news on coral all around the world. In terms of protections, 77,000 square miles of tropical seas will be off limits to fishing thanks to bold conservation action by Papua New Guinea this year.

Located in the legendary Coral Triangle, where the Pacific and Indian Oceans meet, the newly-designated Western Manus Marine Protected Area will form part of the newly established Melanesian Ocean Corridor of Reserves, a network of national and jointly managed protected areas spanning Fiji, Vanuatu, and Papua New Guinea.

The science of coral breeding and restoration is advancing in leaps and bounds. This January, GNN reported that scientists on the island nation of Mauritius are naturally breeding heat-resistant corals that faced a bleaching event last summer with 98% survival rates.

Marine biologists weren’t even able to breed coral in a lab 20 years ago, but recently, scientists on the Maldives bred 10,000 corals in just weeks using a portable station shipped in a container to the archipelago.

In 2022, the breeding of coral took a cosmic leap with the first ever out-of-season spawning event for lab-bred corals along Australia’s northeastern coast.Even just learning about these incredible organisms and what they’re capable of is an ongoing and encouraging process. GNN reported in 2024 that a Nat Geo expedition found the world’s largest coral ever, a leviathan shadow on the seabed that stretched out longer than a blue whale—longer than 4 tennis courts. Scientists Have Found Climate-Resistant Coral Reefs Around the World Totaling the Size of Wisconsin
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Study Finds Many Older Adults Will Improve Over Time–Depending on Their Mindset

Getty Images for Unsplash +

A new study by scientists at Yale University suggests that older individuals can and do ‘improve,’ in all the senses of that word, over time.

Analyzing the results of a large study of older Americans that ran for a decade, a key data point was that the individual’s mindset toward aging plays a major part in their success.

If they believed aging was a process of decline, they declined. If they believed aging was a process of refinement, they improved.


Lead author Dr. Becca R. Levy, PhD, a professor of social and behavioral sciences at the Yale School of Public Health (YSPH) found that nearly half of adults aged 65 and older showed measurable improvement in cognitive function, physical function, or both, over time.

The improvements were not limited to a small group of exceptional individuals and, notably, were linked to a powerful but often overlooked factor: how people think about aging itself.


“Many people equate aging with an inevitable and continuous loss of physical and cognitive abilities,” said Dr. Levy, an international expert on psychosocial determinants of aging health. “What we found is that improvement in later life is not rare, it’s common, and it should be included in our understanding of the aging process.”

The findings are published in the journal Geriatrics.

For the study, the researchers followed more than 11,000 participants in the Health and Retirement Study, a federally supported longitudinal survey of older Americans. The research team tracked changes in cognition using a global performance assessment, and physical function using walking speed—often described by geriatricians as a “vital sign” because of its strong links to disability, hospitalization, and mortality.

Over a follow-up period of up to 12 years, 45% of participants improved in at least one of the two domains, according to the study. About 32% improved cognitively, 28% improved physically, and many experienced gains that exceeded thresholds considered clinically meaningful.

When participants whose cognitive scores remained stable over that period (rather than declining) were included, more than half defied the stereotype of inevitable deterioration in cognition.

“What’s striking is that these gains disappear when you only look at averages,” said Dr. Levy, author of the book 

“If you average everyone together, you see decline,” Dr. Levy continued. “But when you look at individual trajectories, you uncover a very different story. A meaningful percentage of the older participants that we studied got better.”

As for why, Levy and her co-authors hypothesized that an important factor could be participants had assimilated more positive or more negative views about aging by the start of the study. In support of this hypothesis, they found that those with more positive age beliefs were significantly more likely to show improvements in both cognition and walking speed, even after accounting for factors such as age, sex, education, chronic disease, depression, and length of follow-up.

The findings build on Dr. Levy’s stereotype embodiment theory, which posits that age stereotypes absorbed through a range of domains including social media and advertisements eventually become self-relevant and biologically consequential.

Credit: Getty Images for Unsplash+

Dr. Levy’s prior studies have found negative age beliefs predict poorer memory, slower walking speed, higher cardiovascular risk, and biomarkers associated with Alzheimer’s disease. The current study shows that those who have assimilated more positive age beliefs often show improvement, Dr. Levy said.

“Our findings suggest there is often a reserve capacity for improvement in later life,” she said. “And because age beliefs are modifiable, this opens the door to interventions at both the individual and societal level.”

The improvements were not limited to people who started out with impairments. Even among participants who had normal cognitive or physical function at baseline, a substantial proportion improved over time. That challenges the assumption that later-life gains reflect only people getting better after being sick or rebounding from earlier setbacks, the authors said.

The authors hope their findings will reverse the popular perception that continuous decline is inevitable and encourage policy makers to increase their support for preventive care, rehabilitation, and other health-promoting programs for older persons that draw on their potential resilience. https://www.goodnewsnetwork.org/new-study-finds-many-older-adults-can-and-do-improve-over-time-depending-on-their-mindset/
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Sumatran Tiger Cubs Born in the UK Is Huge Win–with Only 400 Left in Wild

credit Tony Kershaw via SWNS

In a valuable milestone for the conservation of the Sumatran tiger subspecies, 3 cubs born to a UK zoo have grown old enough to venture out from the maternity den into the enclosure.

It’s thought there are less than 400 Sumatran tigers remaining in the wilds of Indonesia, and they are considered Critically-Endangered by the IUCN.

Tipah and her litter of cubs – credit Tony Kershaw via SWNS

Howletts Wild Animal Park, in Canterbury, Kent, said the cubs’ births represent an important step forward for the conservation of this cat beyond its natural habitat.

The 3 cubs, 2 girls and 1 boy, were born to first-time mom Tipah and dad Nakal and are just 2 months old.

They were born on April 9th and spent their first few weeks with mom Tipah in their den—but in recent weeks have begun to venture outside to the delight of a photographer there to capture their sensory overload.

“Tipah has taken every step of this journey with calmness, patience and a natural ability to be a fantastic mom,” said Head of Carnivores at Howletts Richard Langston said.

“She spends most of her time up on a platform keeping a watchful eye on them while enjoying a little respite from all the jumping, biting and playing that comes with raising energetic tiger cubs.”

GNN has reported on this cat being born in zoos before—at the Wroclaw and San Diego zoos. It’s considered an important priority animal for captive breeding programs, which have saved many species from extinction in the past.

The park added the cubs were becoming increasingly bold and playful, exploring more of their surroundings and beginning to show their individual personalities.

One cub has already developed an independent streak, often choosing to spend time away from its siblings.

– credit Tony Kershaw via SWNS
  
– credit Tony Kershaw via SWNS
 
– credit Tony Kershaw via SWNS 

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Weight‑loss drugs like Ozempic could work for addiction too – and we finally know how

For many people, the thought of a tasty burger or a cold pint of beer conjures up a vivid mental image and drives behaviour.

This link between thinking and doing serves a clear function – it motivates us to get the necessities for life.

But for some, this process can malfunction. Preoccupation with these rewarding stimuli can lead to disorders of substance overuse, including overeating to the point of obesity and alcohol abuse.

Studies going back to the 1970s have linked vivid mental imagery with drug abuse.

Understanding this link between craving and consuming is central to understanding addiction. This has eluded neuroscience for decades, but the introduction of a new class of drugs for weight loss may have given us just the lever we need to understand it.

These new drugs – including Ozempic and Wegovy – mimic the GLP-1 hormone to stimulate insulin release, slow digestion, and increase feelings of fullness. They are known as GLP-1 agonists and were originally used to treat type 2 diabetes because they help control blood sugar.

As a side effect, people using these drugs also lost a lot of weight, in some cases almost as much as might be expected from bariatric surgery.

But there is another less well publicised effect. Human studies show that GLP-1 agonists reduce alcohol consumption. Preclinical animal studies suggest these drugs also reduce the use of cocaine, amphetamines, opiates and nicotine.

These drugs are changing how we think about the brain’s reward system. They may also open new treatment options for obesity, alcohol dependence and the consumption of other addictive substances.

How the brain regulates reward stimuli

We have a reasonable understanding of the brain’s “reward circuitry” associated with regions that produce the neurotransmitter dopamine.

These brain parts – the ventral tegmental area (VTA) and nucleus accumbens (NAc) – have been the subject of research on reward for decades. They are the obvious candidate regions to look for a mechanism for GLP-1 action in the brain. But they lack significant density of receptors for GLP-1 and are unlikely to be the direct mechanism.

We must, therefore, consider other brain regions to understand the anti-consumption effect of GLP-1 drugs.

One jump “upstream” from the dopamine-producing brain parts is a region called the lateral septum. This brain structure has been historically implicated in emotional regulation.

Back in 1953, pioneering US behavioural researchers Joseph Brady and Walle Nauta coined the term “septal rage” when animals with damage in the lateral septum showed increased aggression, while direct stimulation of this brain region reduced aggression.

Much more recent work has placed the lateral septum at the centre of a neural connectivity network. This has reframed how we think about its function.

While a link between the lateral septum and another region called the hypothalamus is probably responsible for septal rage, the lateral septum links with many other regions with various functions.

The brain’s reward control centre

The lateral septum inherits much of its primary input from a brain region called the hippocampus.

This region is well known as the place that lets us form long-term “episodic memories”. A famous case of hippocampal damage, Henry Molaison (patient HM), was unable to form new memories after his surgery for epilepsy. He effectively lived without a past, in permanent present tense.

The hippocampus also contains the remarkable “place cells” – neurons that fire corresponding to a person’s thoughts about their position in space and, as recent research has shown, time.

This “where and when am I” information gets forwarded to the lateral septum. Key research has recently shown the lateral septum also contains place cells, but these cells strongly respond to rewards. They effectively add “what is good in this place” to the “where and when am I” information from the hippocampus.

Critically, the lateral septum shares this information with the dopamine-producing regions we would normally associate with reward.

Neuroscientists now think of the lateral septum as the brain region that lets us “think about” rewards – our conscious perception of them – and communicates with the machinery in the brain’s reward system that produces dopamine to make us feel good about them.

There is one last reason to suspect the lateral septum as the mechanism behind the anti-consumption effect of GLP-1 agonists. It is absolutely loaded with GLP-1 receptors.

Emerging research points to this as the mechanism. GLP-1 activation directly in the lateral septum has recently been shown to reduce food consumption in mice. Earlier this year, another study showed the same for alcohol consumption.

My own lab has shown this year that GLP-1 drugs reduce a type of activity in the lateral septum that may prevent it communicating so effectively with other brain regions.

These findings are reshaping our understanding of how the brain processes rewards and have put the spotlight firmly on the lateral septum as the home of cravings.The Conversation

Robert Munn, Senior Lecturer, University of Otago

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Want to be a citizen scientist? Here are 5 ways to get involved

Elodie Camprasse, CC BY-ND 

Ever wondered what it might feel like to spot giant spider crabs while you’re snorkelling? Or check plants for the circular holes that indicate native bees are collecting nest materials?

Citizen science relies on people like you – more than a million of them in Australia, actually – to collect and analyse valuable data about the world around us.

Here, we introduce five citizen science projects you can take part in. For most of them, all you need to get started is an app on your phone.

Science lives far beyond the lab, and it’s not just done by scientists.

In this series, we spotlight the world of citizen science – its benefits, discoveries and how you can participate.


Spider Crab Watch

Elodie Camprasse, Honorary Fellow – School of Life and Environmental Sciences – Deakin University

Every winter in Port Phillip Bay in Naarm/Melbourne, tens of thousands of great spider crabs gather in shallow water to moult – shedding their shells and growing new ones that grow to about 16 centimetres. But scientists know surprisingly little about them. The gatherings can be unpredictable and short-lived, making them difficult for scientists to monitor alone.

Spider Crab Watch helps researchers fill these knowledge gaps. By bringing together observations from the public – including divers, snorkellers and fishers – scientists can better understand when and where gatherings occur, how long they last, and what environmental conditions might trigger them.

Citizen scientists have already logged hundreds of observations, helping researchers identify new gathering sites and better understand when aggregations occur. Participants can log when and where they see spider crabs – whether a single crab or a large group, in Port Phillip Bay or elsewhere. Photos are helpful but not essential. Empty shells washed up on beaches can also be logged.

Gatherings of great spider crabs can be fleeting and in different locations. Elodie Camprasse, CC BY-ND

NOBURN

Sam Van Holsbeeck, Research Fellow – Forest Research Institute – University of the Sunshine Coast

NOBURN (the National Bushfire Resilience Network) is a citizen science project aimed at improving our understanding of the role of vegetation in bushfire risk. Using an app, people around Australia can log their observations – including site photographs – to support research into fuel dynamics, fuel load and bushfire risk.

Guided by the app, participants assess vegetation at a site, noting factors such as shrub density and overall fuel hazard. Observations typically take 10–15 minutes and can be conducted by community members, landholders, students or land managers. To date, we have collected 154 verified site observations and more than 160 registered users.

Observations supplied by citizen scientists help researchers understand the structure, density and dryness of forest fuels. Combined with AI, this data allows for better prediction of the likelihood and severity of fires. While this data is not as detailed as a full expert assessment, they provide useful indicative information, particularly in areas where formal fuel monitoring is limited.


FrogID

Jodi Rowley, Curator – Amphibian & Reptile Conservation Biology – Australian Museum – UNSW Sydney

Australia’s frogs are in trouble. At least four species have been lost and dozens more are on the edge of extinction. Yet we lack the information needed to make informed decisions about how to conserve them. Frogs are very sensitive to environmental change. This makes them great indicators of environmental change (they’re often referred to as the “canary in the coal mine”). By monitoring them, we also gain insight into environmental health.

FrogID taps the keen eyes and ears of people across Australia to gather the data needed to help save Australia’s frogs.

Using our free app, people can record frogs wherever they hear them. The best time is after rain and in the first few hours after dark. Once submitted, Australian Museum frog experts listen to the recordings and identify species.

There are more than 100,000 registered users of FrogID who have together gathered almost 1.5 million records of frogs from across Australia. It’s safe to say this dataset has revolutionised our understanding of frogs in Australia – including finding 13 frog species new to science.


1 Million Turtles

James Van Dyke, Associate Professor in Biomedical Sciences – La Trobe University

Freshwater turtle numbers have fallen 60–90% across most of the rivers and wetlands of Australia, amid engineered flows and increasingly dry conditions. As turtles disappear, they leave a large gap. Turtles are the “vacuum cleaners” of the waterways, eating decaying organisms and vegetation and improving water quality.

The 1 Million Turtles project aims to increase survival rates of freshwater turtles and turtle nests, and increase Australia’s turtle population by at least one million animals.

People of all ages can download and record any turtles or turtle nests they see in Australia. They can also volunteer for other activities, such as nest protection, via our website.

To date, our citizen scientists have logged nearly 34,000 turtle records across the country. They have also saved more than 2,600 turtles from dangerous road crossings, and protected more than 1,940 turtle nests from invasive foxes and pigs.

Assuming each nest held an average of 15 eggs, and half of the turtles saved on roads were adult females of reproductive age, our program has given 400,000 turtles the chance of a future in just the past five years.

Data from this community conservation program has led to the conservation status of turtle species being upgraded to threatened or endangered. It has also prompted the development of state conservation programs for turtles in New South Wales, Victoria and South Australia.

A broadshell turtle. Turtles are the ‘vacuum cleaners’ of the waterways, eating decaying organisms and vegetation and improving water quality. James Van Dyke, CC BY-ND

Australian ‘leafcutter’ bees

Kit Prendergast, Research Fellow – School of Science – University of Southern Queensland

Native bee numbers are declining and we have limited information about them. There are more than 2,000 species of native bee, including the Megachile bee. Some species of Megachile bee use plant leaves or even petals to build their nests, giving them the common name of leafcutter bees.

We don’t yet know which plants these bee species rely on. This citizen science project allows the public to use an app to identify which plants the bees are relying on. By noting preferred plants, we’ll have a better idea of how to create habitats for these gorgeous native bees and pollinators.

Most native bees cannot be identified by citizens, due to the specialised skills required, and most diagnostic features being microscopic. But when it comes to plants, these are much better known among the public and can be identified easily by photos.

Members of the public can download the free iNaturalist app and when they see a plant that has distinctive discs cut out, or see a Megachile bee in action, they can take a photo of the leaf “damage”. Once completed, gardeners, land managers and farmers will be able to access an evidence-based list of which nesting plants should accompany food plants.

A megachile native bee cutting a leaf. Lynda Wilson, CC BY-ND

The Conversation

Miki Perkins, Environment & Energy Editor, The Conversation

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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IIT Kanpur-incubated startup inks pact for India’s first 100 pc electric compact tractor

IANS Photo

New Delhi, (IANS): An SIIC IIT Kanpur-incubated startup, ScaNxt Scientific Technologies, entered into an agreement with two institutions under the Ministry of Science and Technology for the technology transfer of India’s first indigenously developed 100 per cent electric compact tractor, a statement has said.

The electric compact tractor, developed with over 90 per cent indigenous components, has been specifically designed for India’s small and marginal farmers.

Conventional diesel-based mechanisation models have historically remained economically inaccessible for small land holders, creating a structural productivity gap across rural India.

India’s agricultural economy remains heavily dependent on smallholder farmers, with over 86 per cent of farming households operating on less than 2 hectares of land.

The tractor integrates a fully electric drivetrain, Vehicle-to-Load (V2L) functionality capable of powering irrigation pumps and farm equipment, compact operational architecture suited for smaller farms, and simplified controls designed to improve accessibility for women farmers.

“Our Smart Compact EV Tractor will dramatically cut cultivation costs, generate green jobs in rural India, and usher in a new era of precision and prosperous farming,” the ScaNxt team said in the statement.

The development also signalled the emergence of a new category within India’s farm mechanisation landscape.

With electric agricultural equipment still at an early stage nationally, the initiative opens opportunities for manufacturing, distribution, servicing, and ecosystem development around sustainable rural mobility solutions.

SIIC IIT Kanpur signed the Memorandum of Understanding (MoU) with CSIR-CMERI and the National Research Development Corporation (NRDC) during the Vigyan Tech 2026 exhibition in New Delhi.

Under the agreement, ScaNxt Scientific Technologies will commercialise the technology under its own brand identity, with a focus on creating an affordable, energy-efficient, and scalable mechanisation solution for India’s rural economy."The agreement reflects the growing maturity of India’s translational innovation ecosystem — where publicly funded research, startup entrepreneurship, and institutional incubation are converging to solve large-scale national challenges through indigenous technologies," the statement noted. IIT Kanpur-incubated startup inks pact for India’s first 100 pc electric compact tractor | MorungExpress | morungexpress.com
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Signs of Breast Cancer Could Be Spotted 3-6 Years Before Diagnosis Using AI Screening, Shows Massive Study

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AI could have detected disease up to 6 years before 2014 breast cancer diagnosis screenings

Early warning signs of breast cancer could have been spotted years in advance using AI, suggests a new study that analyzed 88,963 mammograms performed during a 10-year period on over 31,000 patients.

The researchers showed that the latest artificial intelligence technology can provide an “early alert” for the disease up to six years before a diagnosis.

Swedish researchers tested three commercially available AI-based computer-assisted detection (AI-CAD) radiology systems on the mammogram data.

The findings, published in the journal Radiology, showed that cancer prediction scores issued by AI-CAD were elevated, on average, for people who were eventually diagnosed with breast cancer, while scores were low for those who remained cancer-free.

“Approximately 20% of breast cancer cases demonstrate mammographic signs that are already visible to AI around six years before diagnosis,” said senior co-author Professor Fredrik Strand, of Karolinska University Hospital, Stockholm.

“Our study confirms the potential of AI to, in some cases, find signs of cancer in the mammograms much earlier than when radiologists detected it.”

AI-based systems have shown promise for predicting 5-year risk of breast cancer and identifying women at risk of “interval” cancers between regular screening mammograms, but Prof. Strand’s team looked at their potential to flag mammographic signs that were present up to 10 years (in advance), after collecting mammograms from volunteers aged 40 to 74 across Sweden.

After these volunteer screening exams, two radiologists analyzed each mammogram, which was scheduled every two years—taken between 2008 and 2019.

Across that period, 12,072 of the participants (38.5%) were diagnosed with cancer by radiologist readers.

The AI-CAD systems successfully identified many of those cancers at earlier screening points.

It achieved 90% “specificity” (able to distinguish between a true positive and a true negative result) in nearly 20% of participants six years before their recorded diagnosis, up to 25% of individuals four years before diagnosis and up to nearly 40% two years before diagnosis.

“This study aims to add to the growing literature regarding the application of AI in breast cancer screening and how it can help play a role in earlier detection of breast cancer,” said Strand.

“Analyzing the AI scores of screened individuals over time could provide insight into how early detectable changes arise, potentially allowing for earlier intervention.” Signs of Breast Cancer Could Be Spotted 3-6 Years Before Diagnosis Using AI Screening, Shows Massive Study:
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New Solar Method Turns Ocean Into Drinking Water, While Extracting Valuable Lithium Without Waste

Vials of (left to right) seawater, salt water, nickel sulfate, copper chloride wastewater, and desalinated water with recovered salts – Credit: University of Rochester / J. Adam Fenster

A new energy-efficient desalination system produces fresh water without chemical additives and transforms leftover salts into useful materials.

Communities from California to the Middle East currently rely on desalination plants to convert ocean water to fresh water. But, common desalination techniques—such as reverse osmosis and thermal distillation—are energy-intensive, require chemical water treatment, and leave behind a concentrated saltwater byproduct called brine, which wreaks havoc on sea life if it’s deposited back into the ocean by raising the salt content and lowering oxygen levels.

Now, a novel approach developed at the University of Rochester offers a way to overcome these drawbacks. Their new solar-thermal desalination process does not leave behind brine and requires no chemical additives to pre-treat the water, according to the paper published in Light: Science & Applications.

The technology uses solar panels made of black metal etched with femtosecond lasers to make the surface super light-absorbing and super-wicking, extremely attractive to water.

The panels have a laser-treated active region that pulls a thin layer of water across the surface, absorbs nearly all solar radiation, distills the water, and deposits the leftover salts and minerals into the panel’s untreated sides, leaving the active region unclogged for continuous desalination.

A team led by senior scientist Chunlei Guo, a professor of optics and physics at the university, says other researchers have developed solar-thermal desalination techniques that only work well in lab experiments—using simulated seawater made of only water and sodium chloride. The real ocean is much more complex, and these systems tend to encounter problems when used in the field.

Unlike sodium chloride, many other components in seawater, such as magnesium- and calcium-based materials, crystallize in a crusty and non-porous fashion on the solar panel’s surface—and water can’t seep through anymore. This is the same phenomenon as your shower head clogging over time, except that seawater contains hundreds of times more salts than your tap water.
The ‘coffee ring effect’ makes it self-cleaning

To keep their solar panel surface from gumming up, Guo’s team etched the black metal’s grooves so the various salts and minerals in ocean water would simply slough off. They also leveraged a physical phenomenon java-lovers have encountered for centuries: the coffee ring effect.

“If you drop coffee on a surface, eventually the water evaporates, and there’s a ring left at the outer edge that is the concentrated coffee particles,” says Prof. Guo. “We use that same principle to advance the salts to the passive region.”

Testing their solar-thermal desalination technique using samples of water from the Pacific, Atlantic, and Indian Oceans, Guo and his team were able to make the surface self-cleaning.

Old and new desalination systems – Credit University of Rochester / J. Adam Fenster

It extracted freshwater and directed the remaining salts to where they could be collected without reducing the panel’s efficiency.
Turning waste into resources – like lithium

Another distinct advantage is that instead of leaving behind brine that must be disposed of or processed, it extracts nearly 100 percent of the salts in solid form. This could not only produce an abundant supply of table salt, but it could also be used to extract more precious minerals, including lithium, which helps power electric vehicles and electronics.

“Mining lithium from the earth has proven to be very taxing from an energy and environmental standpoint, so pulling lithium directly from saltwater could be a very important future route,” says Guo.

In a related paper in the Journal of Materials Chemistry, Guo and his colleagues showed how they can use the same super-wicking solar panels to separate lithium from the rest of other salts in desalination.

Embedding nanoparticles made of hydrogen titanate in the tiny grooves of the black metal surface isolates the lithium from other salts and minerals.

Using water samples from Great Salt Lake, the researchers extracted about 50 percent of the lithium from the salts left behind by the desalination process.

Guo sees the technology as inherently scalable, capable of improving global access to drinking water while building a more sustainable supply of precious minerals.“Mining lithium from the earth has proven to be very taxing from an energy and environmental standpoint, so pulling lithium directly from saltwater could be a very important future route.” New Solar Method Turns Ocean Into Drinking Water, While Extracting Valuable Lithium Without Waste:
(The work was funded by the National Science Foundation, the Bill & Melinda Gates Foundation, and Worldwide Universities Network.)
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Critically-Endangered Red Ruffed Lemur Triplets Born at Wild Georgia Theme Park

Red Ruffed Lemur Triplets – credit, Wild Adventure Theme Park

A Critically-Endangered lemur couple has welcomed triplets into their lives at a zoo and theme park in Valdosta, Georgia.

It’s the third year in a row the resident female has given birth at Wild Adventures Theme Park, showing how productive captive breeding programs can be, and how much hope one should have about the future of this beautiful species.

The red-ruffed lemur is many things, all of them interesting or beautiful. At 9.5 pounds, it’s one of the largest extant lemurs, while this heft also makes it the world’s largest pollinator.

It’s fuzzy nose is just perfect for snagging a flower’s pollen and sharing it with another as the animal feeds on fruit and nectar. They’re also one of the most fecund of lemurs, capable of giving birth to litters of 6 at a time, and are the world’s only diurnal primate to stow their infants in nests while going out to forage.

Most cling to their mama as she clambers about.

On April 25th, Taylor, Red, and Marjorie came into the world at Wild Adventures Theme Park, lending their spirits to the 590 or so red ruffed lemurs that live in captivity worldwide.

Their parents, Val and Doug, have welcomed a litter of babies every year since 2023. Taylor, Red, and Marjorie are getting along very well with their siblings Swiper, Raven, Beans, and Dennis.

The species is listed by the IUCN as Critically-Endangered, with some 10,000 remaining in the very northern tip of Madagascar in forests that are rapidly disappearing. Successful breeding between pairs like Val and Doug at Wild Adventures help ensure that if those forests can be saved, there will likely always be lemurs around to inhabit them.“Very soon guests will be able to see Taylor, Red, and Marjorie, alongside their parents in their habitat located near the Giraffe Overlook,” said Asher Raymond, a spokesman for the park. Critically-Endangered Red Ruffed Lemur Triplets Born at Wild Georgia Theme Park
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How waves, ponds and green algae are accelerating sea ice melt in Antarctica

Luke Bennetts, The University of Melbourne; Bonnie Light, University of Washington; Petteri Uotila, University of Helsinki; Philip Reid, Australian Bureau of Meteorology, and Rob Massom, Australian Antarctic Division

Picture sea ice in your mind. You probably imagine brilliant white, snow-covered floes floating on the surface of the ocean, home to penguins in the south of the globe or polar bears in the north.

But our new research shows Antarctic sea ice can turn into rafts of rotting floes (the free-floating pieces of ice) or an icy green slush when it interacts with waves in the stormiest ocean on the planet.

We now know the wave-driven processes that cause the surface of the sea ice to melt are a “missing link” in understanding what’s driving the increasing Antarctic sea ice melt each summer.

These processes can dramatically increase the rate the ice melts, with major implications for the global climate and Antarctic marine ecosystems.

Our planetary heartbeat

Each year, the sea ice that hugs the coast of Antarctica expands from 3 million square kilometres in summer to 19 million square kilometres in winter, stretching far north into the Southern Ocean. As the sun rises and the temperatures increase, it retreats again.

This remarkable seasonal change is like a heartbeat within our planet’s climate system, moderating global temperatures, driving ocean circulation and forming a unique habitat for a plethora of living organisms, all adapted to its seasonal rhythms.

The annual summer sea ice melt is particularly remarkable because it occurs over only three months. But even the most sophisticated climate models underestimate the rapid rate of sea ice retreat each summer.

 
A NASA image from space shows sea ice at its maximum in Antarctica. NASA, CC BY

How do waves melt sea ice?

Until now, the waves travelling from the ice-free ocean into the area covered in sea ice had only been studied for their role in breaking up ice floes. We knew these smaller floes were prone to melting around their sides and bottoms as the ocean was heated by the sun as summer progressed.

But this is not the full story.

We now know waves also flood over ice floes, washing away the bright snow cover that shields the underlying ice from sunlight and creating ponds of seawater on the floe surfaces.

Due to their reduced brightness, the snow-free ice and these “wave ponds” absorb substantially more solar heat than snow-covered ice, and this melts the ice from the top down. Moreover, the snow-free ice and wave ponds are oases in which algae thrive, turning the ice and ponds green and absorbing even more heat from the sun.

The waves also pulverise the floes into small fragments and slush. Under the right conditions, the combination of wave flooding, algal greening and pulverisation turns the sea ice cover into a slushy mixture, resembling a green soup.

We estimate that flooding, ponding and pulverisation can increase summer-time ice thinning by over 4 centimetres per day. Algal greening can add an additional 1 centimetre of thinning per day. These are extraordinary accelerators of ice melt, considering that most Antarctic sea ice is less than 1 metre thick at the end of winter.

Waves are also generated deep within the Antarctic sea-ice region by winds blowing over large openings in the ice cover. In this way, wave melt processes eat away at the ice cover from within, as well as from the edge throughout summer.

 
In this picture of sea ice you can see the effects of wave pulverisation and algae, which darkens the ice. Robert Massom, CC BY-ND

Feedbacks could trigger further melt

Our ice melt estimates are significant, yet they are likely underestimates. They do not account for amplifications to melting caused by so-called “positive feedbacks”.

For example, the ice darkening caused by waves removing the snow, ponding and pulverisation substantially increases the amount of sunlight absorbed by the ice. This causes additional surface and interior melting, which further reduces the ice brightness. And this causes more vertical melting, and so on, in an amplifying cycle.

We propose that this positive feedback is strengthened by algal greening that further darkens the ice, leading to further absorption of sunlight and melting.

Exactly how much these feedbacks would cause further ice melt is tricky to quantify, so we have left this as an exciting future research challenge.

Ponds at both poles

The Antarctic “wave ponds” we have observed are the seawater equivalent of “melt ponds”. These form extensively across Arctic sea ice in summer from pooling snow meltwater.

These freshwater melt ponds have been intensively studied and integrated into climate models, because of their important role in the rapid decline in the coverage and thickness of Arctic sea ice over recent decades.

Unlike melt ponds, seawater wave ponds occur year-round. Although they only occur in regions where sea ice interacts with ocean waves, this encompasses a large proportion of Antarctic sea ice over the course of a year.

The future of Antarctic sea ice

The effects of wave melt, greening and associated feedbacks are likely to intensify on sea ice around Antarctica over coming decades. Climate change is predicted to increase wind speeds and wave heights across the polar Southern Ocean.

This disruption of the annual sea ice cycle and further sea ice loss has serious consequences for global climate and marine ecosystems.

We need further observations using autonomous camera systems on icebreakers and modelling research to better understand these wave processes and their overall influence on Antarctica’s sea ice cycle.

These advances are vital to understanding the causes of recent dramatic sea-ice losses around Antarctica, and promise vital insights about the future of the icy south and our Earth system.The Conversation

Luke Bennetts, Professor of Applied Mathematics, The University of Melbourne; Bonnie Light, Physicist, University of Washington; Petteri Uotila, Professor, University of Helsinki; Philip Reid, Scientist, Australian Bureau of Meteorology, and Rob Massom, Leader, Sea Ice Section, Antarctic Climate Program, Australian Antarctic Division

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Staggering Results Show HIV-Transmission Reduced 100% with Twice-Yearly Lenacapavir Injection


A 2-stage trial testing a new and acclaimed HIV-prevention drug has shown almost unthinkable results of no new infections among a sample size of 3,200 participants.

Called PURPOSE 1, the aim of the first trial was testing a subcutaneous injection of the drug Lenacapavir given twice a year to people in a high-HIV-incidence country, which in this case was Uganda or South Africa.

The results were nothing short of extraordinary—100% efficacy, not a single young woman contracted HIV.

This was followed up by PURPOSE 2, which expanded the geographical area significantly to more countries on more continents, and expanded the pool of individuals from beyond just young women to men—and to those of all ages. 5,000 participants took part.

The result was the same: 99.9% reduction in infection rates.

Both were considered phase 3 clinical trials, and were conducted in a randomized, double-blinded protocol, but were not tested against a placebo. Instead, the Lenacapavir injections were compared to the current standard of HIV prevention—a pill called Truvada or Descovy taken daily.

These both were also found to prevent HIV transmission by 99.9% during development, but must be taken every day to achieve this level of protection. As anyone who’s tried to stick to a once-a-day pill regime long-term will agree, it’s not an easy thing to maintain month after month.

By contrast, the twice-yearly injections are much easier to adhere to, and they also come with the added benefit of removing the social stigma of being seen taking a daily pill and therefore at risk of HIV transmission. This can be particularly alleviating in high-HIV-prevalent countries where male homosexuality is illegal, such as Uganda.

Indeed the superiority of a twice-yearly injection was so clear that both PURPOSE trials were halted early over ethical reasons. A 52-week follow-up screened for HIV developments.

Lenacapavir was named by Science Magazine as the Breakthrough of the Year in 2024, and was approved by the FDA for use in humans under the brand name Yeztugo.

It works to break down the HIVs capsid shell by binding to an “highly conserved” protein on the exterior. That means that no matter how many times or into what form the virus mutates, the exterior shell protein remains—presenting the perfect target for the drug.

In layman’s terms, the drug then works through the protein to disrupt the capsid shell, which the virus ‘takes down’ and ‘builds up’ several times during its lifecycle with perfect geometric precision. The disruption prevents the virus from completing its life cycle.

Initial R&D, regulation compliance, and proof of efficacy and safety requirements mean that producing Lenacapavir has cost its developer, Gilead Sciences, an undisclosed total cost that would be reasonable to estimate at well over a billion dollars based on normal pharma development costs.Gilead has nevertheless committed to providing the drug at cost in certain low-income regions and has licensed generic manufacturers to produce it for approximately $40 per year in 120 low and middle-income countries starting in 2027 Staggering Results Show HIV-Transmission Reduced 100% with Twice-Yearly Lenacapavir Injection
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World’s first AI‑designed vaccine explained

Neil Mabbott, University of Edinburgh

Researchers at the University of Cambridge have developed what they describe as a fundamentally new type of vaccine using artificial intelligence (AI). The vaccine’s key component was designed entirely by AI and has now been tested in people for the first time.

The goal is ambitious: a single vaccine that works not just against all known human coronavirus variants, but against related bat viruses that could jump from animals to humans and cause future pandemics.

Traditional vaccines train our immune system to recognise one specific virus. The problem is that viruses mutate. When they change enough, the vaccine stops working, which is why we need a new flu shot every year and why COVID vaccines have been updated repeatedly since 2021.

AI offers a way around this. By analysing genetic data from thousands of related viruses, it can identify the parts that stay the same across different strains and that are unlikely to change over time. Target those stable features, and you have a vaccine that should work against the whole family, not just the strain you started with.

This is exactly what the Cambridge team did. They used AI to scan viruses from the sarbecovirus family, which includes the viruses that cause both SARS and COVID, as well as a range of animal coronaviruses – looking for shared features that evolution has left largely untouched. Those features became the basis of the vaccine.

DNA vaccines

While many people are familiar with the mRNA shots used during the pandemic, this new vaccine uses DNA. DNA vaccines are generally more stable than mRNA vaccines, making them easier to store and transport. A significant advantage in lower-income countries where “cold-chain” infrastructure is limited.

They can also be administered without needles. A high-pressure stream of liquid delivers the vaccine through the skin, making administration less painful and easier to scale up during an outbreak.

DNA and RNA viruses explained.

Could it protect against future pandemics?

These practical advantages matter most if the vaccine itself can do something no existing jab can: protect against viruses we haven’t encountered yet.

Broad-spectrum vaccines could change the way the world responds to emerging infectious diseases. By offering much wider protection than traditional vaccines, they could provide rapid immunity against new and emerging viral threats. This would equip public health officials with tools to stop future outbreaks in their tracks before they have a chance to turn into global pandemics.

They could also transform our approach to more familiar diseases. Influenza is a prime target because it exists in many different strains and evolves so rapidly. Scientists have to predict which strains will dominate each flu season, and they guess wrong, vaccine effectiveness can suffer. A universal flu vaccine that targets features shared across multiple strains could eventually end the annual race to keep up with the virus.

And the Ebola virus shows why this matters right now. The recent outbreak in the Democratic Republic of the Congo and Uganda is driven by the Bundibugyo strain, which bypasses existing vaccines. While researchers rush to create a new vaccine specifically for this strain, local communities remain at high risk. A broad-spectrum vaccine designed to cover an entire virus family could transform that picture.

What the trial found

This is the first human trial of an AI-designed vaccine. The results showed that this DNA vaccine was able to stimulate the immune system to produce antibodies that can recognise different types of sarbecoviruses. The technology was found to be safe and well tolerated.

This is an exciting advance because it demonstrates how AI has the potential to design variant-proof vaccines against future pandemic threats. The needle-free delivery system could also make the vaccine easier to administer and distribute worldwide.

However, there is more work to do. Although the results in this study are encouraging, the immune responses following vaccination were modest. It was also uncertain how long the protection lasts and whether further boosters will be required. Larger trials are also needed to determine whether the vaccine can prevent or reduce virus infections in the real world.

A universal vaccine remains a few years away. And any new vaccine must still pass larger trials to prove it is safe, effective and provides lasting protection. But this study shows the goal is getting closer – and AI may help us get there faster.The Conversation

Neil Mabbott, Personal Chair of Immunopathology, University of Edinburgh

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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