Deep Sleep Brain Waves Offer Protection Against Alzheimer’s, Shows New Research

Credit: Ruliff Andrean for Unsplash+

Poor sleep quality has been linked to cognitive decline, neuro-degeneration and Alzheimer’s disease in seniors—but it may be possible to counteract certain risks.

A new study shows that specific sleep brain waves provide protection against the harmful effects of a brain chemical associated with wakefulness, sleep transition, and narcolepsy.

Concordia University-led researchers examined levels of the neurotransmitter orexin in the cerebral spinal fluid of 60 adults with mild to moderate Alzheimer’s Disease over a three-year period.

They found that individuals with elevated levels of orexin, which is vital to sleep and appetite regulation, were more likely to exhibit symptoms of cognitive decline, including poorer memory and thinking, more severe behavioral and psychiatric symptoms and had higher levels of biological markers associated with neurodegenerative disease and inflammation.

However, that relationship was found to be mitigated by specific brainwaves during sleep. Individuals who produced stronger sleep spindles and sleep oscillations — types of brainwaves associated with memory support and preservation — during non-rapid eye movement (NREM) sleep had less cognitive decline over time than those with weaker ones.

This sleep activity appears to provide neural resilience against the negative effects of higher levels of orexin on their cognition and mental health.

“This study shows that there is a direct association between orexin levels in the brain and biomarkers of Alzheimer’s disease,” says study co-author Thanh Dang-vu, a neurologist and professor in the Department of Health, Kinesiology and Applied Physiology.

Clear pathways to treatment

The study’s data, published in the journal Neurology, was collected by researchers at Lleida University in Catalonia, Spain. The 60 participants spent a night in a sleep laboratory where researchers recorded their brain activity using overnight poly-somnography. The following morning, cerebrospinal fluid samples were collected to measure orexin and other established Alzheimer’s biomarkers.

Participants also completed a series of cognitive and neuropsychiatric assessments at regular intervals over the next three years, allowing researchers to examine how sleep, brain chemistry and cognitive decline changed together over time.

“Having this longitudinal data is important, because Alzheimer’s disease is a moving target,” says the study’s co-first author Arsenio Paez, a neuroscience lecturer in the Sleep, Cognition and Neuroimaging Lab.

“With this data, we can see how the course of people’s Alzheimer’s disease changes over time. Alzheimer’s is a very long process, so this gives us a better picture of how conditions can change over time and we might intervene at different stages of the disorder.”

The researchers note that orexin-blocking drugs are already being used to treat insomnia and narcolepsy, and are being explored as possible therapies for Alzheimer’s disease.

This study suggests that monitoring sleep spindles, slow oscillations and orexin levels could help measure disease progression and to identify which patients would benefit from specialized treatment.“This study shows us that there are new ways to potentially act on sleep to slow the progression of Alzheimer’s disease, and opens the door for further studies moving forward,” says Dang-vu. Deep Sleep Brain Waves Offer Protection Against Alzheimer’s, Shows New Research

Read More........→September 04, 2026

When Zoo Elephants Are Rewilded in Africa, Here’s How Good Their Coping Skills Are

Rewilded elephants on Khamab Kalahari Reserve – Elephant Reintegration Trust of South Africa / SWNS

New research shows that elephants develop successful coping mechanisms when returning to the wild from human captivity.

In fact, the team found that “rewilded” elephants can fit quite well within wildlife systems and readapt—even after long-term captivity.

For the new study, a team from the Elephant Reintegration Trust of South Africa examined the behavioral and physiological responses of 11 formerly-captive elephants which had been released onto four different reserves.

For five years each elephant was observed for three weeks at a time at least once annually.

The team looked for indicators that the elephants might be uncomfortable in their wild surroundings and for behaviors that might be “hold-overs” from their time in captivity, such as conflict or confrontation.

The findings showed that, overall, rewilded elephants behaved “very similarly” to their wild neighbors.

Fecal samples collected to test for signs of metabolic stress showed levels within the normal range for wild elephants.

“What I found most fascinating was watching elephants that had spent decades in captivity adapt so successfully to life in the wild,” said co-author Tenisha Roos.

“Seeing them respond to their environment and function much like wild elephants was truly awe-inspiring and a powerful reminder of their remarkable resilience, adaptability, and behavioral flexibility.”

Credit – Glen Carrie / Unsplash

The differences may reflect their previous captive experiences, social circumstances, environmental conditions, and tourism or management pressures, according to the research team.

They say their findings, published in the journal PLOS One, show that rewilded elephants behave “very similarly” to their wild counterparts, despite some consistent differences—suggesting that they have adapted well to their return to wild habitats.

The research team also noted a high degree of variability in behavior between individual rewilded elephants, but that might be related to each animal’s personality.

Each elephant likely found their own unique ways to cope with their relocation.

The 11 animals in the study represent more than 50% of the rewilded elephant population across South Africa so far.

“While a few elephants showed slightly elevated stress biomarkers, all values remained within the normal range for wild populations, indicating successful adaptation—with no evidence of chronic stress.”

Andy Rouse captured antics of Kenyan family of elephants – SWNS

Co-author Tammy Eggeling said: “Although previously-captive elephants may carry the memories of confinement, our research has shown that, when given the opportunity, they can leave that past behind.

“They are able to learn new skills, adapt to unfamiliar environments, and ultimately thrive as wild elephants.”

Co-author Brett Mitchell added: “The data from this project show that when captive elephants are rewilded and given the opportunity, they can regain full autonomy and re-establish natural patterns of movement and behavior.“Through this research, we are also seeing that rewilded elephants can make a meaningful contribution to the conservation of their species.” When Zoo Elephants Are Rewilded in Africa, Here’s How Good Their Coping Skills Are

Read More........→August 17, 2026