Signs of Breast Cancer Could Be Spotted 3-6 Years Before Diagnosis Using AI Screening, Shows Massive Study

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AI could have detected disease up to 6 years before 2014 breast cancer diagnosis screenings

Early warning signs of breast cancer could have been spotted years in advance using AI, suggests a new study that analyzed 88,963 mammograms performed during a 10-year period on over 31,000 patients.

The researchers showed that the latest artificial intelligence technology can provide an “early alert” for the disease up to six years before a diagnosis.

Swedish researchers tested three commercially available AI-based computer-assisted detection (AI-CAD) radiology systems on the mammogram data.

The findings, published in the journal Radiology, showed that cancer prediction scores issued by AI-CAD were elevated, on average, for people who were eventually diagnosed with breast cancer, while scores were low for those who remained cancer-free.

“Approximately 20% of breast cancer cases demonstrate mammographic signs that are already visible to AI around six years before diagnosis,” said senior co-author Professor Fredrik Strand, of Karolinska University Hospital, Stockholm.

“Our study confirms the potential of AI to, in some cases, find signs of cancer in the mammograms much earlier than when radiologists detected it.”

AI-based systems have shown promise for predicting 5-year risk of breast cancer and identifying women at risk of “interval” cancers between regular screening mammograms, but Prof. Strand’s team looked at their potential to flag mammographic signs that were present up to 10 years (in advance), after collecting mammograms from volunteers aged 40 to 74 across Sweden.

After these volunteer screening exams, two radiologists analyzed each mammogram, which was scheduled every two years—taken between 2008 and 2019.

Across that period, 12,072 of the participants (38.5%) were diagnosed with cancer by radiologist readers.

The AI-CAD systems successfully identified many of those cancers at earlier screening points.

It achieved 90% “specificity” (able to distinguish between a true positive and a true negative result) in nearly 20% of participants six years before their recorded diagnosis, up to 25% of individuals four years before diagnosis and up to nearly 40% two years before diagnosis.

“This study aims to add to the growing literature regarding the application of AI in breast cancer screening and how it can help play a role in earlier detection of breast cancer,” said Strand.

“Analyzing the AI scores of screened individuals over time could provide insight into how early detectable changes arise, potentially allowing for earlier intervention.” Signs of Breast Cancer Could Be Spotted 3-6 Years Before Diagnosis Using AI Screening, Shows Massive Study:
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Two Steps Forward for Human Space Flight

NASA Signs Agreement for a European-Provided Orion Service Module
NASA signed an agreement in mid-December for the European Space Agency (ESA) to provide a service module for the Orion spacecraft’s Exploration Mission-1 in 2017. When the Orion spacecraft blasts off atop NASA’s Space Launch System rocket in 2017, attached will be the ESA-provided service module – the powerhouse that fuels and propels the Orion spacecraft. “Space has long been a frontier for
Image above: As part of a new agreement between the two space agencies, the European Space Agency will provide the service module for NASA’s Orion spacecraft. Image credit: NASA.
international cooperation as we explore,” said Dan Dumbacher, deputy associate administrator for Exploration System Development at NASA Headquarters in Washington. “This latest chapter builds on NASA’s excellent relationship with ESA as a partner in the  International Space Station, and helps us
Orion Service Module. Image credit: NASA.
move forward in our plans to send humans farther into space than we’ve ever been before.” The agreement primarily maps out a plan for ESA to fulfill its share of operational costs and additional supporting services for the International Space Station by providing the Orion service module and necessary elements of its design for NASA’s Exploration Mission-1 in 2017. Orion’s Exploration Mission-1 animation: There are three major components to the Orion vehicle: the crew capsule, which will carry four astronauts into space on crewed flights and bring them home for a safe landing; the launch abort system, which would pull the crew module to safety in the unlikely event of a life-threatening problem during launch; and the service module, which will house Orion’s power, thermal and propulsion systems. The service module is located directly below the crew capsule and will contain the in-space propulsion capability for orbital
Image above: As part of a new agreement between the two space agencies, the European Space Agency will provide the service module for NASA’s Orion spacecraft. Image credit: ESA, D. Ducros.
transfer, attitude control and high-altitude ascent aborts. It also will generate and store power and provide thermal control, water and air for the astronauts. It will remain connected to the crew module until just before the capsule returns to Earth. “This is not a simple system” said Mark Geyer, Orion Program manager. “ESA’s contribution is going to be critical to the success of Orion’s 2017 mission." Exploration Mission-1 in 2017 will be the first integrated flight test with both the Orion spacecraft and NASA’s new Space Launch System. It will follow the upcoming Exploration Flight Test-1 in 2014, in which an uncrewed Orion will launch atop a Delta IV Heavy rocket and fly to an altitude of 3,600 miles above Earth’s surface, farther than a human spacecraft has gone in 40 years. For the flight test, a test service module is being built by Lockheed Martin. Exploration Mission-1 in 2017 will launch an uncrewed Orion spacecraft to demonstrate the performance of the integrated Space Launch System rocket and the spacecraft prior to a crewed flight. It will be followed by Exploration Mission-2, which will launch Orion and a crew of four astronauts into space. “We have a lot to look forward to in the coming years with human exploration,” Dumbacher said. “NASA is thrilled to have ESA as a partner as we set out to explore our solar system.” Related links: ESA Workhorse to power NASA'S Orion Spacecraft: http://www.esa.int/Our_Activities/Human_Spaceflight/Research/ESA_workhorse, View images from Orion Partnership News Conference: http://www.flickr.com/photos/nasa2explore, View the Orion Service Module Briefing Graphics:http://www.nasa.gov/exploration/systems/mpcv, NASA to Test Bigelow Expandable Module on Space Station: NASA Deputy Administrator Lori Garver announced Jan. 16 a newly planned addition to the International Space Station that will use the orbiting laboratory to test expandable space habitat technology. NASA has awarded a $17.8 million contract to
Bigelow Expandable Module on Space Station
Bigelow Aerospace to provide a Bigelow Expandable Activity Module (BEAM), which is scheduled to arrive at the space station in 2015 for a two-year technology demonstration. "Today we're demonstrating progress on a technology that will advance important long-duration human spaceflight goals," Garver said. "NASA's partnership with Bigelow opens a new chapter in our continuing work to bring the innovation of industry to space, heralding cutting-edge technology that can allow humans to thrive in space safely and affordably." The BEAM is scheduled to launch aboard the eighth SpaceX cargo resupply mission to the station contracted by NASA, currently planned for 2015. Following the arrival of the SpaceX Dragon spacecraft carrying the BEAM to the station, astronauts will use the station's robotic arm to install the module on the aft port of the Tranquility node. After the module is berthed to the Tranquility node, the station crew will activate a pressurization system to expand the structure to its full size using air stored within the packed module. During the two-year test period, station crew members and ground-based engineers will gather performance data on the module, including its structural integrity and leak rate. An assortment of instruments embedded within module also will provide important insights on its response to the space environment. This includes radiation and temperature changes compared with traditional
Bigelow Expandable Activity Module Installation Animation
aluminum modules."The International Space Station is a uniquely suited test bed to demonstrate innovative exploration technologies like the BEAM," said William Gerstenmaier, associate administrator for human exploration and operations at NASA Headquarters in Washington. "As we venture deeper into space on the path to Mars, habitats that allow for long-duration stays in space will be a critical capability. Using the station's resources, we'll learn how humans can work effectively with this technology in space, as we continue to advance our understanding in all aspects for long-duration spaceflight aboard the
Bigelow Expandable Module on Space Station (Artist's view)
orbiting laboratory."Astronauts periodically will enter the module to gather performance data and perform inspections. Following the test period, the module will be jettisoned from the station, burning up on re-entry. The BEAM project is sponsored by NASA's Advanced Exploration Systems (AES) Program, which pioneers innovative approaches to rapidly and affordably develop prototype systems for future human exploration missions. The BEAM demonstration supports an AES objective to develop a deep space habitat for human missions beyond Earth orbit. For more information about Bigelow Aerospace, visit: http://www.bigelowaerospace.com, Images, Videos, Text, Credits: NASA / ESA, D. Ducros / Bigelow Aerospace. Best regards, Orbiter.ch, Publié par Orbiter.ch à Source: Orbiter.ch Space News
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