INST scientists find natural protein that can reshape future of electronic materials


(Photo: PIB)

New Delhi, (IANS) A team of scientists from Institute of Nano Science and Technology (INST), Mohali, an autonomous institute of the Department of Science and Technology (DST), have discovered semiconductor property of a known self-assembling bacterial shell protein could pave the way for safe, environmentally friendly electronics -- from mobile phones and smart watches to medical instruments and environmental sensors.

Traditional semiconductor materials, such as silicon, are valuable technological tools; however, they also have limitations. They are rigid, require high-energy processing, and contribute to the growing problem of electronic waste. Thus, there is increasing demand for sustainable, soft, and biocompatible electronics (wearables, implantable, green sensors).

The INST scientists experimented with self-assembling bacterial shell proteins to explore whether the proteins that naturally form stable, large flat 2D sheets with built-in electron density patterns and aromatic residues could be intrinsically photoactive.

They found that when the proteins form flat, sheet-like films, they absorb UV light and generate an electrical current without any added dyes, metals, or external power and act as light-driven, scaffold-free semiconductors, much like the materials used in electronic circuits and sensors.

Further, the team discovered that these proteins naturally arrange themselves into thin, sheet-like structures. When UV light shines on them, tiny electrical charges begin to move across the protein surface.

“This happens because the proteins contain tyrosine, a natural amino acid that can release electrons when excited by light. As these electrons and protons move, the protein sheet produces an electrical signal -- similar to how a miniature solar cell would operate. This light-driven effect relies on the protein’s internal order and does not require any synthetic additives or high-temperature manufacturing,” said the team led by Dr. Sharmistha Sinha, together with student researchers Silky Bedi and S. M. Rose.

“The discovery opens up exciting possibilities for real-world applications. Because the material is flexible and body-friendly, it could be used to create wearable health monitors, skin-safe UV-detection patches, and implantable medical sensors that work safely inside the human body,” the team said.

In the paper, published in the journal Chemical Science of the Royal Society of Chemistry, the team could also be used in temporary or disposable environmental sensors, such as pollution detectors or sunlight trackers, that naturally break down after use without harming the environment.Families, patients, and consumers may one day benefit from soft, comfortable, and environmentally responsible devices that integrate smoothly into daily life. INST scientists find natural protein that can reshape future of electronic materials | MorungExpress | morungexpress.com
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IIT Bombay’s new smart platform to help researchers decode brain diseases


(Photo: IIT Bombay) IANS

New Delhi, (IANS) A team of bioengineers at the Indian Institute of Technology (IIT) Bombay has developed new smart platforms --BrainProt and DrugProtAI -- that unify data on scattered brain diseases to help researchers find markers, explore treatments, and pinpoint druggable targets.

BrainProt v3.0 is a database that combines various types of biological data -- from genes to proteins -- into a single platform to enable systematic insights into human brain function in both healthy and diseased states.

It is the first system to integrate multi-disease data from genomics, transcriptomics, proteomics, and biomarker research and multi-database information into one portal.

“BrainProt also includes resources to identify and understand protein expression differences between the left and right hemispheres of the human brain across 20 neuroanatomical regions. This is the first resource of its kind,” said Prof. Sanjeeva Srivastava from the Department of Biosciences and Bioengineering, IIT Bombay.

BrainProt includes data on 56 human brain diseases and 52 multi-omics datasets derived from more than 1,800 patient samples. These datasets include transcriptomic data for 11 diseases and proteomic data for six diseases.

For each disease, users can examine genes and proteins frequently associated with the disease, assess how strongly these genes and proteins are already supported by existing medical and scientific databases, and how their activity levels change in patient samples.

DrugProtAI was developed to understand whether a protein can be druggable (has the biological and physical characteristics needed to be a useful drug target) before doing costly experiments.

This is crucial because only about 10 per cent of human proteins currently have an FDA-approved drug, with another 3-4 per cent under investigation.

“Before investing years of work in a protein target, DrugProtAI predicts whether the protein is druggable by looking beyond the protein’s sequence, such as cellular location, structural attributes, and other unique characteristics it has,” said Dr. Ankit Halder, co-author of the study.

The tool generates a “druggability index” -- a probability score indicating how likely a protein is to be druggable. A higher score suggests that the protein shares many properties with proteins that already have approved drugs, while a lower score indicates that drug development would be more challenging.“By integrating DrugProtAI directly into BrainProt, we created a pipeline where researchers can move from identifying a disease marker to examining its expression patterns to evaluating its druggability and exploring existing compounds or clinical trials, all within an hour,” Halder said. IIT Bombay’s new smart platform to help researchers decode brain diseases | MorungExpress | morungexpress.com
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