World’s Smallest Pacemaker is Made for Newborns, Activated by Light, and Requires No Surgery

World’s smallest pacemaker next to a grain of rice – Credit: John Rogers / Northwestern University press releaseNorthwestern University engineers have developed a pacemaker so small that it can fit inside the tip of a syringe and be non-invasively injected into the body, according to a new study published in Nature.Although it can work with hearts of all sizes, the pacemaker is particularly well-suited to the tiny, fragile hearts of newborn babies with congenital heart defects.A pacemaker is an implantable device that helps maintain an even heart rate, either because the heart’s natural cardiac pacemaker provides an inadequate or irregular heartbeat, or because there is a block in the heart’s electrical conduction system.Smaller than a single grain of rice, the pacemaker is paired with a small, soft, flexible, wireless, wearable device that mounts onto a patient’s chest to control pacing. When the wearable device detects an irregular heartbeat, it automatically shines a light to activate the pacemaker.These short light pulses, which penetrate through the patient’s skin, breastbone, and muscles, control the pacing.Designed for patients who only need temporary pacing, the pacemaker simply dissolves after it’s no longer needed. All the pacemaker’s components are biocompatible, so they naturally dissolve into the body’s biofluids, bypassing...
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Scientists Discover Mechanisms That Prevent Autoimmune Diseases and Win $600,000 Crafoord Prize

Autoimmune researcher Professor Goodnow Christopher – Photo by Garvan Institute of Medical ResearchTwo researchers in the US and Australia have discovered important mechanisms that prevent B cells from attacking the body’s own tissues in autoimmune diseases like arthritis, lupus, and multiple sclerosis—and in the process have won a prestigious prize.Normally, the body’s immune system protects us from viruses, bacteria, and foreign substances. However, in autoimmune diseases, the immune system starts attacking tissues in the body instead.Researchers had long tried to discover the cause of autoimmune diseases. But, Christopher Goodnow and David Nemazee, independently of each other, adopted a new approach.They asked why we do not all develop these diseases. Their focus was on B cells which, together with white blood cells and T cells, are the building blocks of our complex immune system.“They have given us a new and detailed understanding of the mechanisms that normally prevent faulty B cells from attacking tissues in the body, explaining why most of us are not affected by autoimmune diseases,” says Olle Kämpe, member of the Royal Swedish Academy of Sciences and chair of the Crafoord Prize committee that awarded the pair 6 million Swedish kronor ($600,000).Neutralize B cellsIn recent years, physicians have started to experiment by...
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