Biologist Finds Beautiful Blue Gecko, Named the New Species 'Vangoghgi'

Cnemaspis vangoghi – Akshay Khandekar

In India’s remote Western Ghats, a gorgeous blue and yellow gecko species has been named in honor of Vincent Van Gogh, whose painting Starry Night, was the first thing that entered Ishan Agarwal’s mind when he saw it.

Found during one of many expeditions into these underdeveloped, underexplored mountains running parallel to India’s western coastline, it enriches both the eyes and the scientific literature.

Belonging to the genus Cnemapsis, it is one of 2,300 members worldwide and over one hundred in India alone. Not so long ago, however, there were only a few dozen.

“We have incredibly diverse fauna, but we know little about it,” Agarwal told Nat Geo of the Western Ghats, in which he has spent 12,400 hours exploring.

Cnemapsis vangoghi was found during one such exploration, after the flash of indigo and mustard yellow which caught Agarawl’s eye.

It looked similar to another gecko of the same genus, C. galaxia, but during lab work, his suspicions were confirmed that it was actually a new species. It and a second, closely related species, are described for the first time in a study published in the natural ZooKeys.

Found in the Srivilliputhur-Megamalai Tiger Reserve, Agarawl suspects that this gecko is receiving much greater protection than many of India’s native reptiles because of its location under the ‘umbrella’ of the charismatic cat.

Umbrella conservation strategies allow naturalists to advocate for the conservation of a single species whose needs of territory, prey species, and protection are largest, and ipso facto helps conserve dozens or even hundreds of other species that share that territory.

In this case, protecting tigers means protecting geckos.

Agarwal says that new techniques for studying DNA allow for much greater specificity in describing species, and that the genus Cnemapsis is “ridiculously diverse.”Biologist Finds Beautiful Blue Gecko, Named the New Species 'Vangoghgi'

Read More........→April 16, 2024

Scientists Discover Potential HIV Cure that Eliminates Disease from Cells Using CRISPR-Cas Gene Editing

HIV-1 virus particles under electron micrograph with H9 T-cells (in blue) – Credit: National Institute of Allergy and Infectious Diseases

A new study has unveiled a likely future cure for HIV which uses molecular scissors to ‘cut out’ HIV DNA from infected cells. To cut out this virus, the team used CRISPR-Cas gene editing technology—a groundbreaking method that allows for precise alterations to a patient’s genome, for which its inventors won the Nobel Prize in Chemistry in 2020. One of the significant challenges in HIV treatment is the virus’s ability to integrate its genome into the host’s DNA, making it extremely difficult to eliminate—but the CRISPR-Cas tool provides a new means to isolate and target HIV DNA. Because HIV can infect different types of cells and tissues in the body, each with its own unique environment and characteristics, the researchers are searching for a way to target HIV in all of these situations. In this study, which is to be presented ahead of this year’s European Congress of Clinical Microbiology and Infectious Diseases, the authors used CRISPR-Cas and two guide RNAs against “conserved” HIV sequences. They focused on parts of the virus genome that stay the same across all known HIV strains and infected T cells. Their experiments showed outstanding antiviral performance, managing to completely inactivate HIV with a single guide RNA and cut out the viral DNA with two guide RNAs. “We have developed an efficient combinatorial CRISPR-attack on the HIV virus in various cells and the locations where it can be hidden in reservoirs, and demonstrated that therapeutics can be specifically delivered to the cells of interest,” said Associate professor Elena Herrera Carrillo from the University of Amsterdam AMC. “These findings

HIV AIDS virus (in yellow) infecting a human cell – Credit: National Cancer Institute

represent a pivotal advancement towards designing a cure strategy.” The team has a long way to go before their cure will be available to patients, but said, “These preliminary findings are very encouraging’. Currently, HIV can be kept in check with anti-retroviral medication, but no one has actually been cured—although three patients receiving stem cell transplants for blood cancer were subsequently declared free of the disease when their HIV became undetectable. “We hope to achieve the right balance between efficacy and safety of this CURE strategy,” said Dr. Carrillo. “Only then can we consider clinical trials of ‘cure’ in humans to disable the HIV reservoir.“Our aim is to develop a robust and safe combinatorial CRISPR-Cas regimen, striving for an inclusive ‘HIV cure for all’ that can inactivate diverse HIV strains across various cellular contexts. Scientists Discover Potential HIV Cure that Eliminates Disease from Cells Using CRISPR-Cas Gene Editing

Read More........→March 26, 2024