A low-cost ventilator for COVID-19 patients

Prototype of the ventilator developed by IISER Pune scientists.

© Umakant RapolResearchers from the Indian Institute of Science Education and Research (IISER) in Pune have designed a prototype for a low-cost, mass-producible mechanical ventilator that could cater to the needs of COVID-19 patients.

They say the ventilator is compatible with wireless technology that facilitates remote monitoring as well as control of the machine.

A number of ventilators can be connected to a central console, allowing healthcare workers to monitor several patients simultaneously – a feature that will be useful during a pandemic, they add. 

COVID-19 patients, particularly elderly ones, need ventilators to ease their breathing problem. A ventilator pumps oxygen into the lungs and then removes carbon dioxide. When the lockdown started in the last week of March, India had serious shortage of ventilators, with experts warning of a disaster if COVID-19 spreads rapidly.

In a response to the a crisis, the IISER Pune team, led by Sunil Nair and Umakant Rapol, set out to build the mechanical ventilator, briskly putting it together within a month. The ventilator, made using equipment available locally, has an electronic system that controls the flow of air volume and with the ability to sense the flow, and to deliver, the desired volume of air into the patient. It also has pressure sensors, a microcontroller for autonomous operation and a microcomputer to interface with the user and with remote monitoring and control. 

The ventilator can work in an invasive mode when a breathing tube is put into a patient’s windpipe through the nose or mouth. It could also function in a non-invasive mode when a patient receives oxygen-rich air through a gas mask.

They demonstrated the efficacy of the ventilator on a test lung. It is possible to monitor the function of the ventilator and the patient’s parameters on a mobile phone.

“The tentative price for a basic unit would be less than Rs. 50,000 which is about 10 times cheaper than the commercial ventilators,” says Nair Source: ttps://www.natureasia.com/
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Glowing nanoprobe detects mercury in bacteria, fish

The fish without the nanoprobe (above) and a confocal microscope image (below) of its body parts after the injection of the nanoprobe revealing the presence of mercury.

Indian researchers have synthesised a light-emitting nanoprobe that can detect minute traces of mercury in various water samples, bacteria and small fish1. The nanoprobe can also remove this toxic metal.

The nanoprobe, they say, is potentially useful for monitoring mercury levels in various fish, including edible ones that transport mercury to humans.
© Panda, S. et al.Fossil fuel burning and various industries emit mercury into the environment, from where it accumulates in fish and other aquatic animals, ending up in humans. Existing techniques for detecting mercury are expensive and complex.

Scientists from the National Institute of Technology in Rourkela and Orissa University of Agriculture and Technology in Bhubaneswar, invented the nanoprobe using modified carbon quantum dots and iron oxide nanoparticles. They then tested the nanoprobe’s efficiency in monitoring mercury in different water samples and in fish.

The researchers, led by Biswaranjan Paital, found that the nanoprobe emitted a feeble green signal in the absence of mercury. However, the green signal became intense in the presence of mercury. The intensity of the signal increased with increasing mercury concentration.

The nanoprobe exhibited a negligible signal in the presence of various metal ions such as sodium, potassium, magnesium and calcium, indicating that it could selectively bind to mercury ions in a solution. Since the nanoprobe contains magnetic nanoparticles, a mercury-attached nanoprobe could be separated using an external magnet.

At high concentrations, the nanoprobe was non-toxic to bacteria, showing that it is biocompatible. It successfully monitored mercury levels in different fish organs such as gills, muscles, the liver and the brain. It also detected mercury levels in bacteria, and tap and river water samples.

References: 1. Panda, S. et al. CQD@γ-Fe2O3 multifunctional nanoprobe for selective fluorescence sensing, detoxification and removal of Hg(II). Colloid. Surface. Physicochem. Eng. Aspect. 589, 124445 (2020). Source: https://www.natureasia.com/
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