Australian-German research finds world-first cure for deadly skin disease

Sydney, (IANS): Researchers from Australia and Germany have for the first time cured patients suffering from toxic epidermal necrolysis (TEN), a deadly skin disease, said a news release on Monday.

An international collaboration, including researchers from the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne and the Max Planck Institute of Biochemistry in Germany, has developed the first-ever cure for TEN in a breakthrough study published in Nature, WEHI said in a news release on Monday.

Also known as Lyell's syndrome, TEN is a rare skin disease that causes widespread blistering and detachment of the skin and can lead to dehydration, sepsis, pneumonia and organ failure, Xinhua news agency reported.

The potentially deadly condition is triggered by a severe adverse reaction to common medications and has a mortality rate of approximately 30 per cent.

The new study identified a hyperactivation of the JAK-STAT signaling pathway - a chain of interactions between proteins in a cell that is involved in processes such as immunity, cell death and tumour formation - as a driver of TEN.

By using JAK inhibitors - an existing class of drugs used to treat inflammatory diseases - they were able to treat patients with TEN.

"Finding a cure for lethal diseases like this is the holy grail of medical research. I am beyond proud of this incredible research collaboration that has already helped to save the lives of multiple patients," Holly Anderton, an author of the study from WEHI, said.

"All seven people treated with this therapy in our study experienced rapid improvement and a full recovery, in staggering results that have likely unlocked a cure for the condition."

Researchers said they are hopeful the findings will pave the way for a clinical trial aimed at the approval of JAK inhibitors as a cure for TEN. Australian-German research finds world-first cure for deadly skin disease | MorungExpress | morungexpress.com

Read More........→November 13, 2024

Scientists Studying Crows Get Big Surprise –They’re So Smart They Understand the Concept of Zero

Chuck Homler, DBA Focus on Wildlife/CC license 4.0

Building on substantial evidence of crow consciousness, a German university has proven some crows can learn to recognize ‘zero’ as a counting unit. While that sounds ridiculous, zero is not nothing, rather it’s one of the most complex mathematical concepts devised—that something can and should represent nothing, not only as the base value, but as a placeholder. The work comes from the University of Tübingen in Germany, where professor Andreas Nieder works with carrion crows to perform intelligence tests. “The conception of “nothing” as number “zero” is celebrated as one of the greatest achievements in mathematics,” wrote Nieder in his paper. “We show that crows can grasp the empty set as a null numerical quantity that is mentally represented next to number one.” Exactly how this breakthrough was made is straightforward and did not involve birds watching Sesame Street. The crows were shown two sets of dots on a screen and were taught to indicate if the two screens had the same values. There could be between zero and four dots. Exactly as with 1, 2, 3, and 4—when the screens showed no dots, neurons in the crow’s brain demonstrated it was understanding this was a numeric value, but that it was a numeric value that contained nothing. Sometimes the crows made mistakes, often by thinking zero was in fact one, but it was rare they thought zero represented more than two. Counting Crows: It took human civilization at least until the 20th century BCE to firmly establish the empty or base value. At some point between the Akkadians and Old Babylonians, there was a symbol to represent a number was missing from a column, for example the 0 in 1,025 doesn’t mean the number is 26, it just means there are no hundreds in this number. As early as 1,770 the Egyptians were making hieroglyphs with the base value “nfr” from which began counting and distances. The ponderous Greeks never managed to capture the concept into their counting, language, or philosophy, meaning that as well as occasionally being smarter than a first grader, these “Counting Crows” were smarter in some ways than the Classical Greeks. Nieder contributed greatly to the current theory of animal consciousness, which is that it’s possible this highest level of thought isn’t necessarily bound to the presence of the cerebral cortex, a cranial region found only in primates, apes, and hominids. In an older experiment he trained two crows to peck at panels following a flash of blue light or red light, but Nieder made the task more difficult by changing the rules constantly, which required the crows to zoom out and look at the task as a whole, rather than simply assigning physical motions to a reward. He would change which light was assigned to which panel, and he would sometimes change the rules before the flash, and sometimes after the flash, constantly interrupting the birds’ base instructions. “These results suggest that the neural foundations that allow sensory consciousness arose either before the emergence of mammals or independently in at least the avian lineage and do not necessarily require a cerebral cortex,” wrote Nieder and the other authors in their corresponding paper published in Science.Scientists Studying Crows Get Big Surprise –They’re So Smart They Understand the Concept of Zero

Read More........→May 01, 2024