COVID-19 likely to become a seasonal disease, say scientists

SEP 19, 2020 WASHINGTON: COVID-19, the illness caused by the SARS-CoV-2 virus, will likely become seasonal in countries with temperate climates, but only when herd immunity is attained, suggests a new review published in Frontiers in Public Health. Until that time, COVID-19 will continue to circulate across the seasons. These conclusions highlight the absolute importance of public health measures needed just now to control the virus. "COVID-19 is here to stay and it will continue to cause outbreaks year-round until herd immunity is achieved. Therefore, the public will need to learn to live with it and continue practicing the best prevention measures, including wearing of masks, physical distancing, hand hygiene and avoidance of gatherings," said senior author of the study Dr. Hassan Zaraket, of the American University of Beirut in Lebanon. Collaborating author Dr. Hadi Yassine, of Qatar University in Doha, affirms and states that there could be multiple waves of COVID-19 before herd immunity is achieved. We know that many respiratory viruses follow seasonal patterns, especially in temperate regions. For instance, influenza and several types of coronaviruses that cause common cold are known to peak in winter in temperate regions but circulate year-round in tropical regions. The authors reviewed these seasonal viruses, examining the viral and host factors that control their seasonality as well as the latest knowledge on the stability and transmission of SARS-CoV-2. The researchers explain that virus survival in the air and on surfaces, people's susceptibility to infections, and human behaviors, such as indoor crowding, differ across the seasons due to changes in temperature and humidity. These factors influence transmission of respiratory viruses at different times of the year. However, in comparison to other respiratory viruses such as the flu, COVID-19 has a higher rate of transmission (R0), at least partly due to circulation in a largely immunologically naive population. This means that unlike the flu and other respiratory viruses, the factors governing seasonality of viruses cannot yet halt the spread of COVID-19 in the summer months. But, once herd immunity is attained through natural infections and vaccinations, the R0 should drop substantially, making the virus more susceptible to seasonal factors. Such seasonality has been reported for other coronaviruses, including those that emerged more recently such as NL63 and HKU1, which follow the same circulation pattern like influenza. "This remains a novel virus and despite the fast-growing body of science about it there are still things that are unknown. Whether our predictions hold true or not remains to be seen in the future. But we think it's highly likely, given what we know so far, COVID-19 will eventually become seasonal, like other coronaviruses," adds Zaraket. "The highest global COVID-19 infection rate per capita was recorded in the Gulf states, regardless of the hot summer season. Although this is majorly attributed to the rapid virus spread in closed communities, it affirms the need for rigorous control measures to limit virus spread, until herd immunity is achieved," Dr. Yassine said. Copyright © Jammu Links News, Source: Jammu Links News
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Strong activation of anti-bacterial cells of immune system linked to severe COVID-19: Study

SEP 29, 2020 LONDON: A type of the immune system's T cells known to fight against bacterial infections is strongly activated in people with moderate to severe COVID-19, according to a study which provides a better understanding of how the body responds to the novel coronavirus infection. Researchers, including those from the Karolinska Institute in Sweden, noted that this component of the immune system called MAIT cells make up about one to five percent of T cells in the blood of healthy people, and are primarily important for controlling bacteria, but can also be recruited to fight some viral infections. They explained that T cells are a type of white blood cells that are specialised in recognizing infected cells, and are an essential part of the immune system. In the current study, published in the journal Science Immunology, the scientists assessed the role played by MAIT cells in COVID-19 disease. They examined the presence and character of MAIT cells in blood samples from 24 patients admitted to Karolinska University Hospital with moderate to severe COVID-19 disease, and compared these with blood samples from 14 healthy controls and 45 individuals who had recovered from COVID-19. Four of the patients died in the hospital, the study noted. "To find potential treatments against COVID-19, it is important to understand in detail how our immune system reacts, and in some cases, perhaps contribute to worsening the disease," said Johan Sandberg, a co-author of the study at Karolinska Institutet. According to the study, the number of MAIT cells in the blood decline sharply in patients with moderate or severe COVID-19, and the remaining cells in circulation are highly activated. Based on these results, the scientists suggested that the MAIT cells are engaged in the immune response against the novel coronavirus SARS-CoV-2. This pattern of reduced number and activation in the blood is stronger for MAIT cells than for other T cells, they said. The study also noted that pro-inflammatory MAIT cells accumulated in the airways of COVID-19 patients to a larger degree than in healthy people. "Taken together, these analyses indicate that the reduced number of MAIT cells in the blood of COVID-19 patients is at least partly due increased accumulation in the airways," Sandberg said. The scientists added that the number of MAIT cells in the blood of convalescent COVID-19 patients recovered at least partially in the weeks after disease, which can be important for managing bacterial infections in individuals who have had COVID-19. They said the MAIT cells tended to be extremely activated in the patients who died. "The findings of our study show that the MAIT cells are highly engaged in the immunological response against COVID-19," Sandberg said. The scientists believe the characteristics of MAIT cells make them engaged early on in both the systemic immune response, and in the local immune response in the airways to which they are recruited from the blood by inflammatory signals. "There, they are likely to contribute to the fast, innate immune response against the virus. In some people with COVID-19, the activation of MAIT cells becomes excessive and this correlates with severe disease," Sandberg added. Copyright © Jammu Links News, Source: Jammu Links News
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